id or Use Alternate Drug. Avoid

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Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Order your refills early to avoid running out of pills.Use this medication regularly to get the most benefit from it. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (1)nabumetone and apixaban both increase anticoagulation. Suttie JW, Mummah-Schendel LL, Shah DV, Lyle BJ, Gregor JL. Use Caution/Monitor. Avoid or Use Alternate Drug. SIDE EFFECTS: See also Warning section.Nausea, easy bruising, or minor bleeding (such as nosebleed, bleeding from cuts) may occur. A Phase II pilot study evaluated the use of apixaban for primary VTE prophylaxis in patients with advanced malignancy receiving either first-line or second-line chemotherapy. Minor/Significance Unknown. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding. Your doctor may switch the type of medication you use during pregnancy.It is unknown if this medication passes into breast milk. The PTT-based lupus anticoagulant and dilute Russells viper venom time were also found to be prolonged in a concentration-dependent manner. Use Caution/Monitor. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZWxpcXVpcy1hcGl4YWJhbi05OTk4MDU=, View explanations for tiers and Adjust dose according to prescribing information if needed. Use Caution/Monitor. Use Caution/Monitor.elagolix will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. If taking apixaban dose >2.5 mg BID, decrease dose by 50% if coadministered with strong dual inhibitors of CYP3A4 and P-gp; if currently taking apixaban 2.5 mg PO BID, avoid coadministration with strong dual inhibitors of CYP3A4 and P-gp. Apixaban or enoxaparin for thromboprophylaxis after knee replacement. Serious - Use Alternative (1)tirofiban and apixaban both increase anticoagulation. Federal government websites often end in .gov or .mil. Use Caution/Monitor. Patients were also excluded if they had received more than two doses of a once-daily LMWH, fondaparinux, or a VKA; more than three doses of twice-daily LMWH; more than 36 hours of continuous intravenous heparin; hemoglobin less than 9 mg/dL, platelet count less than 100,000/mm3, serum creatinine >2.5 mg/dL, or calculated CrCl <25 mL/min. Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents; patients requiring anticoagulation while on imatinib should receive LMWH or unfractionated heparin instead of warfarin because of multiple interaction mechanisms of imatinib with warfarin. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents; patients requiring anticoagulation while on imatinib should receive LMWH or unfractionated heparin instead of warfarin because of multiple interaction mechanisms of imatinib with warfarin. clarithromycin will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of acalabrutinib with antiplatelets or anticoagulants may further increase risk of hemorrhage. Avoid or Use Alternate Drug. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Serious - Use Alternative (1)meloxicam and apixaban both increase anticoagulation. Modify Therapy/Monitor Closely. OReilly R, Rytand D. Resistance to warfarin due to unrecognized vitamin K supplementation. phenobarbital will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. fondaparinux and apixaban both increase anticoagulation. Monitor for adverse reactions if coadministered with P-gp substrates where minimal concentration changes may lead to serious or life-threatening toxicities. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. ritonavir will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Both drugs have the potential to cause bleeding. official website and that any information you provide is encrypted Vitamin K deficiency from dietary vitamin K restriction in humans. Thus, apixaban was proven to be noninferior to standard medical therapy for VTE and superior with respect to bleeding risk. Avoid or Use Alternate Drug. Serious - Use Alternative (1)abciximab and apixaban both increase anticoagulation. Contraindicated (1)St John's Wort will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The ADVANCE-1 and ADVANCE-2 trials were large Phase III clinical trials that evaluated apixaban following TKR for 1014 days. May increase risk of bleeding. Avoid concurrent use of rivaroxaban with other anticoagulants due to increased bleeding risk other than during therapeutic transition periods where patients should be observed closely. Lonafarnib is a weak P-gp inhibitor. lopinavir will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. idelalisib will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Consult your doctor before breast-feeding. Daily use of alcohol while using this medicine will increase your risk for stomach bleeding. Prolongation of these assays is subject to a high degree of variability and should not be used in the routine monitoring of the anticoagulation effect of apixaban. reteplase and apixaban both increase anticoagulation. Agnelli G, Buller HR, Cohen A, et al.AMPLIFY-EXT Investigators Apixaban for extended treatment of venous thromboembolism. Both drugs have the potential to cause bleeding, monitor closely. Modify Therapy/Monitor Closely. Discuss the risks and benefits with your doctor. cilostazol and apixaban both increase anticoagulation. Use Caution/Monitor. Promptly evaluate any signs or symptoms of blood loss if treated concomitantly with low-dose aspiriin. Use Caution/Monitor. rucaparib will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid combined use once INR is established in the desired therapeutic range. Do not double the dose to catch up. Coadministration may increase risk for adverse effects of CYP3A4 substrates. tolmetin and apixaban both increase anticoagulation. Use Caution/Monitor. indinavir will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Learn more Reduce P-gp substrate dose if needed.Serious - Use Alternative (1)lonafarnib will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. This does not include use for routine maintenance or reopening of central venous lines. Monitor Closely (1)melatonin increases effects of apixaban by anticoagulation. Modify Therapy/Monitor Closely. The primary safety outcome was major bleeding as defined by International Society on Thrombosis and Haemostasis, and the secondary safety outcome was the composite of major or CRNM bleeding.21 Symptomatic recurrent VTE or death from VTE occurred in 8.8% of the placebo arm compared to 1.7% receiving 2.5 mg of apixaban (RR 0.19 [95% CI 0.110.33], P<0.001) and 1.7% of the patients who were receiving 5 mg of apixaban (RR 0.20 [95% CI 0.110.34], P<0.001). Use Caution/Monitor. Economic burden of venous thromboembolism in hospitalized patients. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Use Caution/Monitor. anagrelide and apixaban both increase anticoagulation. Avoid or Use Alternate Drug. Small molecule antidote for anticoagulants [abstract]. Avoid or Use Alternate Drug. Use Caution/Monitor. The new PMC design is here! Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. You may report side effects to Health Canada at 1-866-234-2345. Either increases effects of the other by anticoagulation. Adjust dosage of CYP3A4 substrates, if clinically indicated. Serious - Use Alternative (1)nelfinavir will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Patients with a bileaflet aortic valve with major risk factors for stroke, CHADS2 score of 3 or 4, or VTE within the past 312 months or active cancer are intermediate risk (4%10% annual risk of ATE or 4%10% per month risk of VTE). encorafenib, apixaban. Use Caution/Monitor. Consider dose reduction of sensitive CYP3A4 substrates.istradefylline will increase the level or effect of apixaban by P-glycoprotein (MDR1) efflux transporter. This effect was not observed with istradefylline 20 mg/day. Either increases toxicity of the other by Other (see comment). Monitor Closely (1)lonafarnib will increase the level or effect of apixaban by P-glycoprotein (MDR1) efflux transporter. dexamethasone will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. vorapaxar increases toxicity of apixaban by anticoagulation. Avoid or Use Alternate Drug. primidone will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. In the AMPLIFY study, only 2.5% in the apixaban group and 2.8% in the conventional therapy group had active cancer.24 In the AMPLIFY-EXT study, only 1.1%2.2% of patients had active cancer, and subgroup analysis was not performed.25 Moreover, the comparator group was placebo rather than continuation of at least prophylactic anticoagulation which most would advocate in patients with active cancer and a history of recent VTE. Use Caution/Monitor. Serious - Use Alternative (1)nirmatrelvir/ritonavir will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Contraindicated. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Avoid or Use Alternate Drug. Abbreviations: VTE, venous thromboembolism; ATE, arterial thromboembolism; AVR, aortic valve replacement; MHV, mechanical heart valve; CHADS2, congestive heart failure, hypertension, age >75 years, diabetes mellitus, stroke history; TIA, transient ischemic attack. Use Caution/Monitor. Contraindicated. Reduces anticoagulant effect by decreasing apixaban systemic exposure. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Perioperative management of antithrombotic therapy. Schulman S, Kearon C. on behalf of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Hylek E, Held C, Alexander J, et al. If taking apixaban dose >2.5 mg BID, decrease dose by 50% if coadministered with strong dual inhibitors of CYP3A4 and P-gp; if currently taking apixaban 2.5 mg PO BID, avoid coadministration with strong dual inhibitors of CYP3A4 and P-gp. Avoid or Use Alternate Drug. Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)desirudin and apixaban both increase anticoagulation. stiripentol will increase the level or effect of apixaban by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)fexinidazole will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tell your doctor right away if you have any signs of serious bleeding, including: nosebleeds that happen often or don't stop, unusual tiredness/weakness, unusual pain/swelling/discomfort, unusual bruising, prolonged bleeding from cuts or gums, unusually heavy/prolonged menstrual flow, pink/dark urine, coughing up blood, vomit that is bloody or looks like coffee grounds, severe headache, dizziness/fainting, bloody/black/tarry stools, difficulty swallowing.Get medical help right away if you have any signs of very serious bleeding, including: vision changes, confusion, trouble speaking, weakness on one side of the body.A very serious allergic reaction to this drug is rare. Use Caution/Monitor. Apixaban is FDA-approved for the primary prevention of DVT, which may lead to PE, following hip or knee replacement surgery based upon the following trials. Use Caution/Monitor. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Avoid or Use Alternate Drug. Apixaban is currently FDA-approved to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, for the prophylaxis of DVT, which may lead to PE, in patients who have undergone TKR or THR, for the treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE following initial therapy. Avoid or Use Alternate Drug. enzalutamide will decrease the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. affecting hepatic/intestinal enzyme CYP3A4 metabolism. To date, no published RCTs have addressed the use of reversal agents for apixaban, and current evidence for TSOAC reversal is primarily extrapolated from in vitro experiments and animal models. Revankar N, Patterson J, Kadambi A, et al. Consult your pharmacist or local waste disposal company. Contraindicated. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Serious - Use Alternative (1)fenoprofen and apixaban both increase anticoagulation. If taking apixaban dose >2.5 mg BID, decrease dose by 50% if coadministered with strong dual inhibitors of CYP3A4 and P-gp; if currently taking apixaban 2.5 mg PO BID, avoid coadministration with strong dual inhibitors of CYP3A4 and P-gp. Consider reducing the dosage of P-gp substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. A meta-analysis of randomized trials. Serious - Use Alternative (1)meclofenamate and apixaban both increase anticoagulation. If taking apixaban dose >2.5 mg BID, decrease dose by 50% if coadministered with strong dual inhibitors of CYP3A4 and P-gp; if currently taking apixaban 2.5 mg PO BID, avoid coadministration with strong dual inhibitors of CYP3A4 and P-gp. For patients receiving apixaban 5 mg BID, avoid coadministration with combined P-gp and strong CYP3A4 inhibitors. Serious - Use Alternative (1)voxelotor will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If use is unavoidable, refer to the prescribing information of the P-gp substrate for dosage modifications. Avoid or Use Alternate Drug. A: Generally acceptable. Use Caution/Monitor. sulindac and apixaban both increase anticoagulation. Risk stratification for perioperative arterial or venous thromboembolism29,30. Consider reducing the dosage of P-gp substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Contraindicated. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. Serious - Use Alternative (1)piroxicam and apixaban both increase anticoagulation. Serious - Use Alternative (1)sulindac and apixaban both increase anticoagulation. Serious - Use Alternative (1)ibuprofen and apixaban both increase anticoagulation. Reduces anticoagulant effect by decreasing apixaban systemic exposure. Avoid or Use Alternate Drug. Properly discard this product when it is expired or no longer needed. nintedanib increases effects of apixaban by anticoagulation. Use Caution/Monitor. The elimination half-life is prolonged in renal impairment.13,1517 Additional pharmacokinetic details are delineated in Table 1. Modify Therapy/Monitor Closely. Short-term coadministration may be needed for patients transitioning to or from edoxaban. Thus, the ADVANCE-2 trial established noninferiority of apixaban in the setting of VTE prophylaxis for TKR. Use Caution/Monitor. Monitor Closely (2)elagolix will increase the level or effect of apixaban by P-glycoprotein (MDR1) efflux transporter. US Department of Health and Human Services . Avoid or Use Alternate Drug. Currently, no evidence-based guidelines exist for the management of apixaban in the perioperative setting. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. eptifibatide and apixaban both increase anticoagulation. Serious - Use Alternative (1)quinidine will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. MISSED DOSE: If you miss a dose, take it as soon as you remember. Avoid or Use Alternate Drug. Sardar P, Chatterjee S, Chaudhari S, Lip G. New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized trials. Monitor Closely (1)sertraline and apixaban both increase anticoagulation. Monitor Closely (2)stiripentol, apixaban. Coadministration of defibrotide is contraindicated with antithrombotic/fibrinolytic drugs. Individual characteristics leading to one or all of this triad include advanced age, prolonged immobility, previous VTE, pregnancy or the postpartum state, cancer, hospitalization, surgery, trauma, and thrombophilia.5. affecting hepatic/intestinal enzyme CYP3A4 metabolism. nefazodone will increase the level or effect of apixaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Medscape Education, Preventing Pediatric Venous Thromboembolism in Post-Fontan Patients: An Evolving Paradigm, encoded search term (apixaban (Eliquis)) and apixaban (Eliquis). Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Use Caution/Monitor. Based on the mechanism of action, Factor X is likely to be counteracted by direct and indirect Factor Xa inhibitors. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Reduce apixaban dose by 50% when mifepristone used for treatment of Cushing's disease or other hormonal conditions; if patients are already receiving 2.5 mg twice daily, avoid coadministration. If taking apixaban dose >2.5 mg BID, decrease dose by 50% if coadministered with strong dual inhibitors of CYP3A4 and P-gp; if currently taking apixaban 2.5 mg PO BID, avoid coadministration with strong dual inhibitors of CYP3A4 and P-gp.

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