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/Parent 3 0 R >> Face sunscreens tend to have lighter and thinner formulas. /C2_0 42 0 R /Font << J Clin Oncol. /CS0 [/Separation /Black /DeviceCMYK 59 0 R] /ITXT (4.2.0) /TT2 38 0 R /Contents 66 0 R Here are a few key things to consider: Dermatologists agree that the best sunscreen for you is the one you apply consistently. /BleedBox [0 0 595.276 782.362] /Parent 3 0 R We were unable to use specific epithelial cytokeratin markers in quantitative PCR since the signals fell below the detection levels. /Annots [98 0 R] /Font << /C2_1 61 0 R >> >> We also compare the results of this assay with an already-established imaging assay. 0000005972 00000 n We first compared the already established imaging technique with quantitative PCR and ddPCR in a head-by-head experiment. /C2_1 61 0 R /C2_0 61 0 R 4, Additional file 1: Table S5). /Font << Baseline monitoring of organic sunscreen compounds along South Carolinas coastal marine environment. /C2_2 39 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] Consumer Reports suggests a reef-safe label can be misleading in general, as the Food and Drug Administration (FDA) currently doesnt have an agreed-upon definition, and this factor isnt strictly regulated by the government. Nat Protoc. SPF helps protect your skin from those rays year-round. Reapply more often if youre sweating or swimming. 0000015529 00000 n /XObject << >> /TT0 60 0 R onlinelibrary.wiley.comtrue2021-05-0610.1111/phpp.12688 0000091599 00000 n This can be problematic if you want a product that lasts long. /Parent 3 0 R /ArtBox [0 0 595.276 782.362] What Causes Rosy Cheeks and How Is It Managed? /Rotate 0 Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer. Considerations: It contains potentially irritating ingredients, according to the Environmental Working Group (EWG), which publishes information on personal care products through its Skin Deep database. Key features: At an affordable price and available in many stores, Neutrogenas Ultra Sheer Dry-Touch Sunscreen has a non-greasy feel, an SPF of 70, and water resistance for up to 80 minutes. The doseresponse effect shown here and the differing responses to anti-cancer drugs enhance the reliability of the new assay. /MC1 93 0 R Active ingredients in Bare Republic Mineral Sunscreen Lotion, Face, SPF 70: Key features: This sunscreen comes in the form of a small solid that you can swipe on. By using this website, you agree to our /TT1 60 0 R /ProcSet [/PDF /Text] J Transl Med 17, 235 (2019). Proc Natl Acad Sci USA. /TT2 38 0 R We tested two primary and corresponding metastatic head and neck squamous cell carcinoma (HNSCC) cell lines and patient-derived tongue cancer sample applying zebrafish larvae xenograft model. 1 0 obj /MC1 96 0 R /T1_0 37 0 R /Font << Vital tissue pieces were placed into a new petri dish containing HBSS and minced into small (12mm) pieces with a scalpel. A fresh tissue sample was obtained perioperatively and placed in a 50-ml falcon tube containing ice-cold Hanks Balanced Salt solution (HBSS; supplied with 100 U/ml penicillin, 100g/ml streptomycin and 250ng/ml fungizone). 6 0 obj /Type /Page PCR-based zebrafish model for personalised medicine in head and neck cancer. 2018;68:394424. >> /MC0 73 0 R << >> 0000085309 00000 n /Contents [25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R] Informed consent was obtained from each patient prior to study onset. We used both quantitative PCR, which is easy and available in almost all research and hospital laboratories, and ddPCR, which is more accurate and could detect mRNA at a very low expression level [16]. >> /Length 3380 /Type /Pages /ExtGState << J Exp Clin Cancer Res. Current treatment options for recurrent or metastatic head and neck squamous cell carcinoma. Well show you what keratosis pilaris, or chicken skin, looks like, as well as its causes, symptoms, treatment options, and home remedies. Jung DW, Oh ES, Park SH, Chang YT, Kim CH, Choi SY, et al. endobj Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. endobj Despite these positive findings, some drawbacks continue to surround this model, including the evaluation technique of the drug response. endobj Van Ginkel JH, Huibers MMH, van Es RJJ, de Bree R, Willems SM. The time required for conducting quantitative PCR of 100 fish was 4.6h which is around five times less than the imaging assay (21.3h, Additional file 1: Table S4). trailer <]/Prev 879286>> startxref 0 %%EOF 248 0 obj <>stream /Fm1 63 0 R /MediaBox [0 0 595 842] /Font << Our institutional Research Ethics Board (14.03.2016 Eettmk 84) approved this study setting. A lot of effective sunscreens are out there. /TT1 60 0 R Sunscreen should be a critical part of your everyday skin care regimen, so having a facial moisturizer with built-in SPF helps streamline your routine. /ArtBox [0 0 595.276 782.362] /ColorSpace << Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. /Contents 92 0 R /Resources << /MC3 79 0 R Here are our picks for the best year-round sunscreen sprays to protect you and your family, from sensitive skin to environmentally friendly. Active ingredients in CannaSmack Ink Guard, SPF 30: If youre going to spend any time outside, sunscreen is a must. 0000085943 00000 n /MC1 72 0 R /Fm1 44 0 R For quantitative PCR, 10-l iQ SYBR green, 7-l water and 1l of 250nM of a primer solution were added to 2l of a cDNA sample. The evaluation of the cisplatin effect on a human tongue UT-SCC-24A tumour xenograft using imaging technique (a 6 fish for each group), quantitative PCR (b 20 fish for each group, with 10 fish pooled together) and ddPCR (c20 fish for each group, with 10 fish pooled together). Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, et al. Droplets (40l) were then transferred to a 96-well PCR plate, sealed with the supplied foil in a PX1-PCR Plate Sealer instrument (Bio-Rad) and placed into the T100 Thermal Cycler (annealing temperature=60C). 0000033119 00000 n Other ingredients include beeswax and plant oils to keep skin hydrated. For example, a 2014 study found that octocrylene might be harmful to developing zebrafish. /ProcSet [/PDF /Text] After 2h of incubation, the tube was centrifuged and the supernatant was discarded and replaced with a fresh HBSS buffer before another round of centrifugation. endobj /Pages 3 0 R /TrimBox [0 0 595.276 782.362] >> >> In practice, this model appears superior to the mouse xenograft, which takes several weeks to establish drug testing. Body sunscreens will work the same on your face, but they might feel heavy. /Annots [19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R] 2013;13:453. /Rotate 0 >> Tissue samples were stored on ice until further processing. /Fm0 62 0 R Considerations: This sunscreen is formulated without parabens, synthetic fragrances, mineral oil, sulfate detergents, phthalates, urea, DEA, or TEA. 5 0 obj BMC Cancer. /ProcSet [/PDF /Text] All data and results of this study are available from the corresponding author upon reasonable request. /BleedBox [0 0 595.276 782.362] Study design: AA, TS, KM, TW, AM, and RG. All authors read and approved the final manuscript. /Contents 58 0 R The zebrafish larvae were treated with 1-phenyl 2-thiourea (PTU) for imaging to avoid pigmentation. For droplet digital PCR (ddPCR), 10l of QX200 EvaGreen ddPCR Supermix (Bio-Rad Laboratories) and 1l of 900nM of a primer were added to 2l of a cDNA sample. /WPS-ARTICLEDOI (10.1111/phpp.12688) Therefore, personalised treatment of cancer patients in general and HNSCC patients in particular remains a necessity. /C2_1 42 0 R A T-shirt, rash guard, or cover-up not only blocks more UV rays from your skin, but also reduces the amount of sunscreen you need to apply (and reapply) to the exposed parts of your body. >> /Parent 3 0 R 0000008793 00000 n /XObject << Considerations: One big drawback of this product is the price tag. application/pdfdoi:10.1111/phpp.12688 >> /Fm0 67 0 R >> 12 0 obj 0000013739 00000 n Therefore, we employed ddPCR, which successfully detected cytokeratin 17 mRNA. Progesterone activation of zebrafish mineralocorticoid receptor may influence growth of some transplanted tumours. Our website services, content, and products are for informational purposes only. /ExtGState << Bratkovics S, et al. 0000014177 00000 n For imaging purposes, cells were stained using CellTrace Far Red (Invitrogen, Carlsbad, CA, USA) according to the manufacturers instructions. Active ingredient in Stream2Sea Sunscreen Sport, SPF 30: Key features: This option is safe for sensitive skin and offers impressive broad spectrum SPF 100 protection. /ColorSpace << All the sunscreens on this list are under $30, except for the Colorescience powdered sunscreen. /CreationDate (D:20210505172359+05'30') /ProcSet [/PDF /Text] Cancer survival in Europe 19992007 by country and age: results of EUROCARE5-a population-based study. 0000007022 00000 n >> 0000003727 00000 n Like the Bare Republic lotion mentioned above, this sunscreen stick offers mineral-based sun protection. Fior R, Pvoa V, Mendes RV, Carvalho T, Gomes A, Figueiredo N, et al. >> 0000014769 00000 n This is considered safer for marine life because the larger size is less likely to affect their systems. /Parent 3 0 R 0000010343 00000 n Until recently, the zebrafish larvae model has primarily been used to study cancer cell proliferation, metastasis, tumour angiogenesis and drug testing [9, 13, 14]. A novel zebrafish human tumour xenograft model validated for anti-cancer drug screening. Cells were cultured in 75cm2 flasks containing Dulbeccos modified Eagles medium (DMEM)/F-12 (Gibco, Paisley, UK) supplied with 10% heat-inactivated foetal bovine serum (FBS), 100 U/ml penicillin, 100g/ml streptomycin, 250ng/ml fungizone and 50g/ml ascorbic acid. /ProcSet [/PDF /Text] The tissue pieces were transferred to 15-ml falcon tube and centrifuged for 5min at 1000rpm (200g) at 4C. /ProcSet [/PDF /Text] It also claims to prevent color fade and dehydration with ingredients like hempseed oil. >> /GS0 35 0 R /T1_0 37 0 R /C2_0 42 0 R For patient-derived tumour samples specifically, we found that using ddPCR could be more precise in detecting the signal from epithelial cancer cells alone. /MC1 76 0 R 0000005056 00000 n Correspondence to ): For example, one dollar sign means you get more product for the money spent, while products that cost a bit more might meet other needs besides budget. /CropBox [0 0 595.276 782.362] Varner J. Proc Natl Acad Sci USA. << /MC0 83 0 R Drug screening results of four HNSCC cell lines and patient sample revealed different drug efficacy between tested cancer cells. Mast cell activation syndrome can cause temporary allergic symptoms in multiple organ systems. In this work, we developed the assay further by suggesting the PCR-based technique, which is easier and faster than the imaging assay. 0000006492 00000 n /MC1 47 0 R /Resources << All rights reserved. Considerations: While the company boasts that the product formulas have been tested and found reef-safe, keep in mind that there is no set standard or regulatory group for such concerns. Al-Samadi, A., Tuomainen, K., Kivimki, A. et al. 2017;22:8738. 0000018170 00000 n /Xi1 46 0 R Int J Pharm. /TT0 60 0 R /GS0 35 0 R /Properties << The curve showed a perfect negative correlation between the cisplatin dose and the human GAPDH signal (r=0.96, Fig. Drug concentrations were chosen based on our previous in vitro drug testing as well as on the cytotoxicity test for the zebrafish larvae (Additional file 1: Table S2). /BleedBox [0 0 595.276 782.362] >> /C2_0 61 0 R 2019;48:41936. The pink shades might make it look like you have a sunburn already, depending on how you apply them. /Resources << Healthline Media does not provide medical advice, diagnosis, or treatment. After 3months, a CT scan showed no signs of recurrence or metastasis. Sunscreen vs. Sunblock: Which One Should I Use? /C2_0 61 0 R 8 0 obj /MediaBox [0 0 595.276 782.362] 2017;114:E823443. 0000007487 00000 n And if you like products backed by experts, know that this sunscreen has received praise from the Skin Cancer Foundation. /Resources << 4, Additional file 1: Table S5). >> endobj In this study, we used two primary and two metastatic HNSCC cell lines (kindly provided by Dr. Reidar Grenmans lab, University of Turku, Additional file 1: Table S1). Dose-dependent response of the tumour xenograft to cisplatin treatment evaluated using quantitative PCR. Zebrafish as a model to assess cancer heterogeneity, progression and relapse. >> 0000129602 00000 n /TT0 60 0 R Active ingredients in Avne Solaire UV Mineral Multi-Defense Sunscreen Fluid, SPF 50: For more options for sensitive skin, check out what our dermatologists had to say. Active ingredients in Supergoop! /MC0 97 0 R /Resources << endobj 2017;17:428. Even if its not summer, and you dont feel the sun burning on your skin, ultraviolet (UV) rays never take a day off. /Properties << /BleedBox [0 0 595.276 782.362] It also contains Avena sativa (oat) kernel flour, an ingredient that can be an irritant or allergen for some users. CK 17=cytokeratin 17. However, its not in high concentrations in this product. endobj The Skin Cancer Foundation recommends that you apply sunscreen about 30 minutes before heading outdoors, and reapply every 2 hours for optimal effectiveness. Samples, in addition to the Droplet-Generation Oil for EvaGreen (70l), were loaded into DG8 cartridges and placed into a QX200 Droplet-Generator (Bio-Rad Laboratories) for individual droplet generation. /MediaBox [0 0 595.276 782.362] Study concepts: AA, TS, KM, TW, AM, RG, and MP. /GS1 36 0 R << The tumour response was evaluated using a quantitative PCR method. >> >> /CropBox [0 0 595.276 782.362] /Subject (Photodermatology, Photoimmunology & Photomedicine 0.0:null-null) /XObject << endobj /TrimBox [0 0 595.276 782.362] This possibility may provide preliminary knowledge for the clinician regarding the most suitable and personalised choice of available drugs for a specific patient in a time-efficient manner. 0000076873 00000 n >> 2012;8:19309. Manuscript preparation: AA. /Type /Page /CS0 [/Separation /Black /DeviceCMYK 59 0 R] For this assay, we used the zebrafish GAPDH as the housekeeping gene, which remained stablebetween the groups. /Contents 95 0 R If you buy through links on this page, we may earn a small commission. /MC0 94 0 R Box 63, 00014, Helsinki, Finland, Ahmed Al-Samadi,Katja Tuomainen,Anne Kivimki,Abdelhakim Salem,Sakhr Al-Kubati&Aini Hyytiinen, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland, Oral and Maxillofacial Unit, Tampere University Hospital, Tampere, Finland, Department of Oral and Maxillofacial Surgery, HUS Helsinki University Hospital, Helsinki, Finland, Department of Otorhinolaryngology Head and Neck Surgery, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland, Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Department of Otorhinolaryngology Head and Neck Surgery, Turku University Hospital, University of Turku, Turku, Finland, Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland, Medical Research Centre, Oulu University Hospital, Oulu, Finland, Helsinki University Hospital, Helsinki, Finland, You can also search for this author in FDA Approves First At-Home Treatment for Skin Repigmentation in People With Common Type of Vitiligo. A reduction in the mRNA expression was plotted as a percentage relative to the control (100%). endstream Heres our process. Active ingredients in Neutrogena Ultra Sheer Dry-Touch Sunscreen, SPF 70: Key features: Offering the convenience of sunscreen application on the go, this spray provides broad spectrum SPF 50 protection (meaning it blocks both UVA and UVB rays) from four active ingredients, plus a boost of antioxidants, like vitamin C. Considerations: Coverage may be a concern. /TT0 40 0 R Cisplatin efficacy was tested using imaging technique and compared the results with PCR-based methods. Clin Cancer Res. /CropBox [0 0 595.276 782.362] /Parent 3 0 R A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, showing promising results in drug testing against patient-derived tumour xenografts. Considerations: This sunscreen contains zinc oxide. /ExtGState << /GS1 36 0 R /ExtGState << PCR-based zebrafish model for personalised medicine in head and neck cancer, https://doi.org/10.1186/s12967-019-1985-1, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. /Rotate 0 These have the same effective ingredients youll find in other sunscreens, plus they come in neon colors or metallic shimmers. /TT0 40 0 R >> For the patient-derived (xenograft) tumour cells, cisplatin yielded a modest effect (46% reduction) and the targeted-therapy (EGFR and mTOR inhibitors) revealed a strong effect (8090% reduction, Fig. Data analysis and interpretation: AA, AK, AS, SA, AH, and MP. /Fm2 43 0 R PubMedGoogle Scholar. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. This model carries several advantages, including a large number of offspring, a small size (can fit in a 96-well plate), a short experimental duration, a low cost and the possibility of completing high-throughput testing. Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens. Due to the limited availability of ddPCR and since it produced comparable results to quantitative PCR, we continued our assays using the quantitative PCR technique in order to provide an assay which could be easily adopted in most research and clinical facilities. /C2_2 39 0 R 0000002457 00000 n endobj /Creator (Adobe InDesign CC 2015 \(Windows\)) 0000025191 00000 n /Rotate 0 % Lancet Oncol. Quality control of data and algorism: AA, KT, and AK. Experiments were done at the Zebrafish Unit at the University of Helsinki under the ethical permission (ESAVI/13139/04.10.05/2017) given by the regional state administrative agency. /GS0 35 0 R >> /Fm1 63 0 R /ArtBox [0 0 595.276 782.362] 0000045265 00000 n Next, the sealed plate was transferred to the QX200 Droplet Digital PCR Systems (Bio-Rad Laboratories) to detect the completed PCR reactions in droplets. 0000013203 00000 n 0000015930 00000 n One tiny drawback? Based on these results, we continued the drug testing with quantitative PCR given its convenience and wide availability in most research laboratories. Drugs were diluted in the embryonic medium and DMSO was used as the negative control. The use of zebrafish larvae for drug testing in oncology and for personalised medicine specifically showed promising results, particularly in terms ofsimulating real patient responses [7, 9]. Additional file 1: Table S3 summarises the primer sequences. >> /MediaBox [0 0 595.276 782.362] 10 0 obj 0000047914 00000 n >> Necrotic tissues were removed using a scalpel. Some users might not like the classic vanilla coconut scent. 0000085564 00000 n /GS1 35 0 R Cisplatin emerged as the most effective drug in almost all cell lines, while Afatinib showed no activity in any of the cell lines tested (Fig. 3 0 obj /Type /Page Considerations: Keep in mind that the smaller size means it might not provide enough sunscreen for your face or body on your travels, especially if youre spending a long weekend under a tropical sun. Currently, primary treatment of HNSCC patients consists of surgery and (chemo)radiotherapy either alone or in combination [2]. /BleedBox [0 0 595.276 782.362] Droplet digital PCR for detection and quantification of circulating tumour DNA in plasma of head and neck cancer patients. /MC0 65 0 R /MC0 70 0 R >> This may affect the drug efficacy in some cancers, such as an endocrine-dependent cancer, which should be kept in mind when evaluating the results [17]. Manuscript editing and review: All the authors. CAS /TT3 41 0 R 2022 BioMed Central Ltd unless otherwise stated. Mineral sunscreens have the advantage of blocking UV rays more quickly than chemical sunscreens. >> The hard plastic bottle and size make it easy to pack. /ColorSpace << 0000062288 00000 n The patient had metastatic oral tongue cancer (Additional file 1: Table S1). Each group had 20 fish, with 10 fish pooled together. In total, 400ng of RNA were used for the cDNA synthesis using an iScript cDNA synthesis kit (Bio-Rad, Hercules, CA, USA). 2016;17:95665. Next, we evaluated the dose-dependent response to cisplatin. /Resources << /TrimBox [0 0 595.276 782.362] >> Using a more sensitive ddPCR method, we detected cytokeratin 17. M:Mz98lB However, these treatments still offer limited efficacy given that 5-year survival amongst HNSCC patients is around 50% [3]. >> (2019). /Fm1 68 0 R /C2_0 42 0 R /Fm0 62 0 R Unfortunately, until now no practical in vivo system existed for testing cancer-drug efficacy in a patient sample. /Type /Page We know shopping for sunscreen can be overwhelming almost every skin care line offers one, after all. Considerations: Hempseed oil aside, this sunscreen contains other uncommon ingredients, such as meradimate. /C2_0 42 0 R /Type /Page Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. 7 0 obj Provided by the Springer Nature SharedIt content-sharing initiative. The primary limitation of the present zebrafish xenograft assay is the different species between the host and the original species (human). /C2_1 39 0 R /Fm2 43 0 R Play Antioxidant Body Mist, SPF 50: Key features: This SPF 50 sunscreen lotion offers up to 80 minutes of water-resistant protection against UVA and UVB rays. /CS0 [/Separation /Black /DeviceCMYK 59 0 R] Teng Y, Xie X, Walker S, White DT, Mumm JS, Cowell JK. << /ViewerPreferences << Dis Model Mech. Here, we introduce an easy, fast and low-cost PCR-based in vivo assay to test anti-cancer drug responses in patient-derived tumour samples. /TT0 40 0 R This method goes hand-by-hand with the commonly used imaging assay. BMC Cancer. /TrimBox [0 0 595.276 782.362] Active ingredients in Colorescience Sunforgettable Brush-On Sunscreen, SPF 50: Key features: This sunscreen is lightweight, and leaves skin feeling silky and smooth, while also minimizing the appearance of pores. >> Find out if kids need different sunscreens from adults, if sunscreen can be toxic, and whether it matters if youre slathering on SPF 100. Several users, for example, say the fluid has a sticky texture and white color, which may not be great if you like to wear sunscreen under makeup. /Rotate 0 Drug screening of eight compounds was applied on both cell lines and patient sample using PCR. The authors declare that they have no competing interests. >> /Properties << /GS2 75 0 R So this tinted sunscreen might not be the best product choice if youre going to be outdoors or spending long periods of time in the water. >> This allows users to wear it alone or underneath makeup as a primer. (2014). /BleedBox [0 0 595.276 782.362] /TT1 40 0 R hb```b``cb`c` B@1vF /Type /Page /ExtGState << https://doi.org/10.1186/s12967-019-1985-1, DOI: https://doi.org/10.1186/s12967-019-1985-1. /Parent 3 0 R These moisturizers, sunscreens, toners, and more will help keep your skin in top shape this summer. >> >> 0000135279 00000 n /MediaBox [0 0 595.276 782.362] /ArtBox [0 0 595.276 782.362] All of these factors encourage researchers to shift towards using zebrafish larvae in their experiments. /BleedBox [0 0 595.276 782.362] How long does sunscreen last? /TT1 40 0 R /CropBox [0 0 595.276 782.362] >> /ExtGState << Play Antioxidant Body Mist, SPF 50, Aveeno Baby Continuous Protection Sensitive Skin Zinc Oxide Sunscreen, SPF 50, Coppertone Pure & Simple Kids 100% Mineral Sun Protection, SPF 50, Bare Republic Mineral Sunscreen Lotion, Face, SPF 70, Bare Republic Mineral Sunscreen Stick, SPF 50, La Roche-Posay Anthelios Melt-In Milk Sunscreen, SPF 100, Avne Solaire UV Mineral Multi-Defense Sunscreen Fluid, SPF 50, Black Girl Sunscreen Moisturizing Sunscreen Lotion for Face and Body, SPF 30, Colorescience Sunforgettable Brush-On Sunscreen, SPF 50, Tatcha Silken Pore Perfecting Sunscreen, SPF 35, Glossier Invisible Shield Daily Sunscreen, SPF 35, Unsun Mineral Tinted Broad Spectrum Face Sunscreen, SPF 30, Healthlines picks of the 15 best sunscreens for all year round, Coppertone Pure and Simple Kids 100% Mineral Sun Protection, SPF 50, skincancer.org/skin-cancer-prevention/sun-protection/sunscreen/, skincancer.org/blog/ask-the-expert-does-a-high-spf-protect-my-skin-better/, skincancer.org/blog/ask-the-expert-how-much-sunscreen-should-i-be-using-on-my-face-and-body/, ewg.org/sunscreen/best-sunscreens/best-beach-sport-sunscreens/, sciencedirect.com/science/article/abs/pii/S0048969714000242?via%3Dihub, sciencedirect.com/science/article/abs/pii/S0025326X15300850?via%3Dihub, cancer.org/latest-news/choose-the-right-sunscreen.html, tandfonline.com/doi/abs/10.1080/10937404.2017.1290516?journalCode=uteb20, ewg.org/skindeep/ingredients/704203-octinoxate/, ewg.org/skindeep/ingredients/704206-octocrylene/, ewg.org/skindeep/ingredients/704372-oxybenzone/, gundersenhealth.org/health-wellness/publications/gundersen-magazine/spring-2018/physical-vs-chemical-sunscreens/, aad.org/public/everyday-care/sun-protection/, cancer.org/cancer/cancer-causes/radiation-exposure/uv-radiation.html, sutterhealth.org/ask-an-expert/answers/how-long-does-sunscreen-last, 16 Summer Skin Care Products Healthline Editors Cant Live Without, The 19 Best Moisturizers with SPF in 2022, Every Sunscreen Question You Have, Answered.

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